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The ESI Scheme in the North Eastern States was implemented as far back as in 1958, under the Regional Office, West Bengal. It was in the early 70s that an independent Region was created for North East Region, with its Regional Office at Guwahati. Initially, the Scheme was implemented in 5 (five) Centers in the state of Assam. Gradually, with the continuous and optimum efforts, the Scheme had been extended to the whole of the state of Assam and to the state of Meghalaya in the year 1980. Thereafter, the Scheme was extended to the state of Nagaland in the year 2008,  Tripura in the year 2009. Mizoram in the year 2015 and Manipur in the year 2018. As on date, the Scheme is yet to be extended to the 1 (one) state of the North East India, which is Arunachal Pradesh. Optimum efforts are being taken for extension of the Scheme in Arunachal Pradesh as well. 

As of the latest report, the number of employees/Insured Persons has crossed the 2 (two) lac threshold and the figure is on the increasing trend. There is vast improvement in the field of Medical Benefit also. Apart from the ESIC Model Hospital, located at Beltola, Guwahati, which is one of the best hospitals in the country, there are 5 (five) tie-up hospitals for Secondary Treatment and 10 (ten) tie-up hospitals in Assam, 01 (one) in Meghalaya, 04 (four) in Mizoram and 01 (one) in Manipur for Super Specialty Treatment. For Primary Care also, there are 31 (Thirty One) ESI Dispensaries and 1 (one) ESIS Hospital spreadted across all the 6 (six) implemented states. For providing Cash Benefits and beneficiary related services, apart from the Regional Office, Guwahati, there are 22 (Twenty Two) Branch Offices across the 6 (six) states of the Region.

Under the IT Roll Out Programme, the Scheme is progressing smoothly. Registration of employers and employees are now being done 100% online. All payments, such as Benefit Payments, Third Party Payments, Personal Claims, etc. are also being made through online only, thereby reducing much hassles and problems for the beneficiaries.